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Applications of HPMC


Concept of HPMC

Hypromellose is a solid, slightly off-white to beige powder in appearance, and can be made into granules. This compound forms colloids when dissolved in water. This non-toxic component is flammable and can react violently with oxidizing agents.

Hypromellose in aqueous solution, like methylcellulose, has thermal gelation properties. That is, when the solution is heated to a critical temperature, the solution condenses into a nonflowable but semiflexible substance. In general, this critical (freezing) temperature is inversely proportional to the solution concentration of HPMC and the concentration of methoxy groups in the HPMC molecule (which in turn depends on the degree of substitution and the molar substitution of the methoxy groups). That is, the higher the concentration of methoxyl groups, the lower the critical temperature. Rigidity/viscosity However, the amount of mass obtained is directly related to the concentration of methoxyl groups (higher concentrations give more viscous or less flexible masses)

What is HPMC used for?

1. For whole wheat bread

Scientists at the Agricultural Research Service are investigating the use of plant-derived HPMC as a gluten substitute in whole oat and other grain breads. [citation needed] Gluten, which is found in wheat, rye, and barley, is absent (or only present in trace amounts) in oats and other grains. Like gluten, HPMC traps air bubbles formed by yeast in bread dough, allowing bread to expand.

2. Use in building materials

HPMC is mainly used in construction materials, such as tile adhesives and plasters, as a rheology modifier and water retention agent. HPMC is functionally very similar to HEMC (hydroxyethyl methylcellulose), and trade names include Methocel and Walocel. The world's leading producer is now DuPont, formerly produced by Dow Wolff Cellulosics GmbH.

3. Ophthalmology application

Hypromellose solution was patented as a semi-synthetic substitute for the tear film. Its molecular structure is based on highly water-soluble basic celluloid compounds. Celluloid properties with good water solubility are reported to aid in visual clarity after application. When applied, the hypromellose solution swells and absorbs water, which expands the thickness of the tear film. Thus, increased hypromellose would result in a longer lubricant presence on the cornea, which would theoretically lead to less eye irritation, especially in dry climates, home or work environments. At the molecular level, this polymer contains beta-linked D-glucose units that keep metabolism intact for days to weeks. In terms of manufacturing, since hypromellose is a vegetarian alternative to gelatin, production costs are slightly higher due to the semi-synthetic manufacturing process. In addition to its wide commercial and retail availability, over the counter in various products, hypromellose 2% solution has been documented to help protect the cornea during surgery and orbital surgery.

4. Excipients/Tableting Ingredients

Besides its use in ophthalmic fluids, hypromellose is also used as an excipient in oral tablets and capsules, and depending on the grade, it acts as a controlled release agent to delay the release of pharmaceutical compounds into the digestive tract. It is also used as an ingredient in binders and tablet coatings


Price of HPMC

Particle size and purity will affect the product's price, and the purchase volume can also affect the cost of particle size. A large amount of large amount will be lower. The price of particle size can be found on our company's official website.


HPMC supplier

Luoyang Tongrun Nano Technology Co. Ltd. (TRUNNANO) Luoyang City, Inwin-style, China, is a reliable and high-quality global chemical material supplier and manufacturer. It has more than 12 years of experience providing ultra-high quality chemicals and nanotechnology materials, including Zinc sulfide, nitride powder, Zinc sulfide powder, sulfide powder, and 3D printing powder. If you are looking for high-quality and cost-effective HPMC, you are welcome to contact us or inquire at any time.

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